Antibodies are one of the body’s first lines of defense against infection, but their role in tuberculosis (TB) has gone largely unstudied. Now, by harnessing a unique technology for rapidly analyzing human antibodies, a team of researchers led by Harvard T.H. Chan School of Public Health and the Ragon Institute of MGH, MIT, and Harvard University has uncovered key differences in antibodies isolated from different groups of TB patients—findings that could spur new diagnostic tools and open a new scientific path towards an effective TB vaccine.“Our work shatters some long-standing paradigms on TB,” explains co-senior author Sarah Fortune, professor of immunology and infectious diseases at Harvard Chan School and director of TB research at the Ragon Institute. “That means we’ll need to think differently about how the body develops natural immunity to the infection and how effective vaccines should be engineered.”About a third of the world’s population carries the bacteria that cause TB, known as Mycobacterium tuberculosis or Mtb. In 2014, nearly 10 million people worldwide became newly infected with Mtb and 1.5 million died. Although there are drugs that can treat the infection, drug-resistance is a pervasive problem and the most potent tool for long-term TB control—a vaccine—remains an elusive goal.Fortune and her colleagues set out to answer a couple simple questions about antibodies in TB: First, are they different in people who are actively sick with TB versus those who can control the infection? Read Full Story
…Johnson hits second consecutive centuryTHE Georgetown Cricket Club (GCC) produced a clinical performance to whipped GDF by an innings and 142 runs in the latest round of the GISE/Star Party Rental/Trophy Stall First-Division two-day match yesterday at the Georgetown Cricket Club, ground Bourda.Scores in the match: GDF 87 and 94; GCC 323-4 declared.Earlier, play was delayed by almost three hours due to rain. However, when the second days play resumed, the hosts took their overnight 274-2 to 323-4 declared, an overall first innings lead of 236runs.Overnight batsmen, former West Indies batsman and current Guyana Jaguars Captain Leon Johnson and Mavindra Dindyal took the total to 322, a third-wicket stand of 176 runs during which the left-handed Johnson registered his century. It was his second consecutive century since the tournament resumed.On the other hand, Dindyal, who was one of three Guyanese who toured with the West Indies Under-16 squad recently to the UK, took his overnight, from 60, to 68 before he was trapped leg before to Joshua Jones. Ronaldo Ali-Mohamed was then stumped off Leon Andrews without scoring.His dismissal triggered the declaration, leaving Johnson unbeaten on 108. His innings lasted for 123 balls with seven fours and six maximums.At that point, the visitors’ temperament and mental toughness to perform with the bat was always going to be under pressure. However, against a good bowling attack, GDF batsmen failed for a second time in two days.They succumbed to off-spinner Stephon Wilson, who ripped the heart of their batting lineup, claiming 5-45, to follow up his first innings figures of (3-38).\Damion Waldron (22), former Guyana Under-19 all-rounder, Jones (20) and Randy Lindore (19), reached double figures for the Soldiers. Timothy McAlmont, Johnson and Zachary Jodah all clamied a wicket apiece in the commanding win.
Los Angeles, United States | AFP | Floyd Mayweather has accused Conor McGregor of “fighting dirty” in training but is confident of a clean battle when the two men meet in their August 26 superfight.Mayweather told reporters on a conference call on Thursday he believed mixed martial arts star McGregor had used illegal tactics in sparring sessions.The undefeated former welterweight king, who is coming out of retirement to fight McGregor in Las Vegas, said he had spotted rabbit punches in footage of McGregor’s sparring session with Paulie Malignaggi.McGregor, who has never fought in a professional boxing contest, appears to floor Malignaggi in the footage.Mayweather, 40, was unimpressed.“I had a chance to see it and my thought were, it was interesting,” Mayweather said of McGregor’s Malignaggi knockdown.“A lot of rabbit punching, a lot of illegal shots, behind the head,” he added.McGregor has hired veteran referee Joe Cortez during his training camp to help advise on boxing rules and ensure he fights clean.“He’s had Joe Cortez in his training camp and I’ve still seen him being extremely dirty,” Mayweather said. Veteran referee Robert Byrd will be responsible for managing the fight and Mayweather is confident he will maintain control of the contest. Byrd officiated in Mayweather’s 2013 win over Robert Guerrero in Las Vegas.“I truly believe the referee is going to do a great job,” Mayweather said.“The referee’s job is to keep the fight clean. He don’t have anything to worry about. I’m looking forward to following the Queensberry rules of boxing,” he added.Mayweather retired from boxing in 2015 with a perfect 49-0 record to emulate former heavyweight legend Rocky Marciano. A win against McGregor would see the welterweight become the only man to ever hold a perfect 50-0 record.Mayweather insisted however that moving clear of Marciano’s historic benchmark was not on his mind.“Even though this is my 50th fight, this is not my focus,” Mayweather said. “Rocky Marciano is a legend, he did it his way. I just like to do it the Mayweather way.”Win or lose, Mayweather is adamant that nothing will be able to tempt him back into the ring following his return against McGregor. He reiterated an earlier statement that this month’s fight will be his last.“This is my last one. I gave my word to (adviser) Al Haymon, I gave my word to my children, I don’t want to break that,” Mayweather said.“I’m going to stick to my word — this is going to be my last fight.”Share on: WhatsApp
Two federal agencies are investigating The Home Depot after receiving reports that its contractors did not comply with lead paint regulations.WSB-TV, a television station in Atlanta where Home Depot is headquartered, said that it spent months investigating claims of “questionable business practices” and uncovered a number of customer complaints about contract work involving the removal of lead paint.In one instance, Home Depot was hired to replace windows in an older home in Augusta, Maine, and charged extra for the work after tests showed the presence of lead paint. But workers allegedly took no special precautions and used no special equipment. In that case, the company settled with the homeowner, and the Occupational Safety and Health Administration fined both Home Depot and the contractor who did the work, the station said.Lead paint was common until 1978, when the federal government banned its use in homes. Later, the EPA issued the Renovation, Repair and Painting Rule, which includes a number of requirements for contractors aimed at protecting people, especially children, from lead. RELATED ARTICLES Lead-Based Paint and Green RemodelingManaging Lead Paint HazardsEPA Steps Up Enforcement of Lead Paint Rule Home Depot said in a filing in March that it was aware the EPA was looking into its compliance with lead-paint rules, MarketWatch reported. A Home Depot representative told the Atlanta TV station that lead-paint work makes up only a very small fraction of its total business and that it was cooperating with the investigation.The retailer isn’t the first home improvement business to run afoul of the federal lead-paint rule. In a similar case, Sears settled with the EPA and the Department of Justice in 2016 by agreeing to pay $400,000 for violating the rules.
AI: How it’s Impacting Surveillance Data Storage Brad is the editor overseeing contributed content at ReadWrite.com. He previously worked as an editor at PayPal and Crunchbase. You can reach him at brad at readwrite.com. Experiences have flooded the marketplace. Whether they’re investing in pop-up stores or festivals, brands have recognized the major shift happening. The IPA Bellwether Report found that in the U.K., experiential marketing was the only area to experience significant growth in spend in 2017 besides internet marketing.Similarly, EventTrack found that American consumers gravitated toward the brands that gave them experiences to savor, with 74 percent reporting they were more likely to purchase from brands engaging them with experiences. In fact, 98 percent admitted they created social content when they participated in these experiences — and all of those who created content also shared content.The writing’s on the wall for companies that have paid attention. These experiences can be beneficial to brands of every type, and Surkus is determined to use technology to make experiential accessible.Abandoning the Spray-and-Pray ModelSurkus classifies three major areas as experiential: branding experiential (such as pop-ups), ticketed experiences (such as concerts or festivals), and immersive experiences (such as VR). In working with brands that launch experiences in every category, Surkus focuses on making the strongest matches it can between its members and its clients.It does that through technology. The brand’s platform uses an algorithm to identify the right audience members for each experience being offered. By curating a group that’s expressed interest in a certain subject or a similar brand, Surkus pinpoints the members who will feel excited about the opportunity.That translates to a win for Surkus’ client companies. Surkus’ focus on targeting the right audience makes both attendance and engagement possible. Clients can ask for a variety of engagements — social content, surveys, market research — with Surkus enabling communication between clients and members throughout every point of a campaign.“We don’t need to complicate things, but simplify them,” explains Stephen George, Surkus’ CEO. “We want to make sure the right audience is attending and engaging, and we know the little things are our clients’ entire objective in working with us. It doesn’t have to be complex.”Capitalizing on What They’ve GotSurkus’ knowledge of where members are at every touchpoint is valuable: By tracking members’ locations and activity, the platform can nudge them and offer reminders. The platform, designed for Instagram posts, can point out that a member, still at an event, just took 50 photos and should post one of them. If the member exited the venue, the client can ask questions to get real-time feedback on how the installation or product played in front of its audience.“It’s important to be able to time our interactions and engagements correctly,” George says. “In the moment, members shouldn’t be interrupted so they can absorb the experience. But there hasn’t been an easy way to transfer instantaneous reactions. Brands don’t want to target people when they walk in or when they’re in the middle of a performance — they’re not going to get very good information.”But good information is there for the taking. George points to concerts as an example: If a concert producer spent the majority of his budget on the closing act and the grand finale fireworks, but 40 percent of concertgoers left two hours before the encore, Surkus can provide that data to the producer so he can reconsider where he’s spending his money. While Surkus’ goal with members is to provide them with compelling experiences, the brand’s focus for clients is driving long-term value.“If brands have already planned out the production of their events and are wasting money at certain times, we need to be able to tell them,” George explains. “They may be able to restructure the production to use the same layout of money but increase engagement. And the longer we can keep people engaged, the more ancillary revenue that drives — but there’s also a better experience because there’s no lag in the event itself.”Bringing Experiential to the MassesTechnology has made things more affordable, particularly through automation. Surkus itself thrives on this fact: While a PR agency helping with experiential activations can handle 20 clients at one time, Surkus can work with 10,000. “Bodies just aren’t as efficient as our algorithm,” George says.This sheer volume helps every activation under Surkus’ umbrella — as its base grows, so does its data collection. This enables Surkus to give first-timers a head start by giving them insight into what’s worked well for similar types of events or which types of audience members responded best. But, as George says, that data becomes more meaningful as clients repeatedly work with Surkus to launch experiences; the brand can provide continuous data on who engaged or took actions so constant tweaks can occur.The affordability and ease created by technology hasn’t completely trickled down, and George says that’s created a misconception that lingers among small brands. “There’s a perception that events have to be grandiose, multimillion-dollar affairs that only global brands can afford,” he says. “It can be a small mom-and-pop retailer with a pop-up event, and that can be just as enticing as Under Armour launching a $1 million activation at its store. The point is targeting the people who will respond.”Brands from small businesses to international conglomerates should be fitting experiential into their budgets, regardless of the size. While attention is paid to experiences offered by Netflix, Anheuser-Busch, or LiveNation, anyone can do it, George points out, and platforms like Surkus enable the same types of results for brands of every size.Smaller brands that refuse to invest in experiential, in fact, will run into a universal problem: ad blockers and other tools that allow consumers to bypass marketing. With people skipping commercials regularly and billboards simply not having the reach they should for their cost, experiential has become a more affordable way to stick in consumers’ minds. Surkus’ platform offers a la carte services, allowing clients to determine what’s most important in terms of engagement and what fits within their budget. Getting one attendee to walk through the door at an event can cost as little as $3. After an era of spray-and-pray advertising, with money sprinkled everywhere, experiential can result in reverse sticker shock.What’s NextBringing experiential to the masses also means expanding markets, and that’s next on Surkus’ agenda. George, the former co-founder and head of operations for Groupon, says the Los Angeles-based business launched in Boston last month and is “relaunching” in San Francisco in October.“A lot of our markets in the past grew organically, but now we’re announcing launches in targeted areas — we’re highly dedicated to these new markets,” George says. The brand also has an eye on global growth and serving its clients in any market they’re operating in; beyond its office in Hong Kong, Surkus plans to expand to Singapore in the next few months.That reinforces the company’s belief that experiential isn’t necessarily what people think it is — and it’s not outside anyone’s reach. By incorporating technology to make experiential activations more affordable and accessible, Surkus just may have found a way to bring personalized experiences to the masses. Trends Driving the Loyalty Marketing Industry Brad AndersonEditor In Chief at ReadWrite Tags:#branding#customer experience#CX#event marketing#experiential marketing#festival#marketing#pop-up shop How Data Analytics Can Save Lives AI is Not the Holy Grail of Sales, at Least Not… Related Posts
About the authorFreddie TaylorShare the loveHave your say Liverpool aiming for Carabao Cup success insists Lijndersby Freddie Taylora month agoSend to a friendShare the loveLiverpool are hoping to win the Carabao Cup, even if they do make changes to their team for the early rounds.The Reds will take the approach of many top Premier League sides by involving young and fringe players into the starting lineups for the competition.But assistant boss Pepijn Lijnders insists they are serious about winning the games and progressing deep into the Carabao Cup.He told the club’s website about their ambitions: “We want to compete in each competition, we want to attack each competition. We worked so hard to be in this situation where we can compete in each one. “For me, cup competitions are the soul of football because it represents a chance for smaller clubs to play against Premier League clubs and can give historic games for fans. That’s what we’re up against tomorrow. “The cup competitions are something special; when two local teams play against each other, that environment you get with the cup competitions. “We want to attack this cup, we want to attack tomorrow’s game, we will put a team in place that, for me, is a Premier League team. The players feel this responsibility as well: a highly-motivated team plays against us and the players feel this responsibility, so they really look forward to it, I really look forward to it. “It’s another opportunity to put our identity in place and show our passion. “We prepare for the game in the same way we prepared for Chelsea, with the same access, probably even more detail, but with the same hunger to win it.”
ARLINGTON, TX – APRIL 04: Head coach John Calipari of the Kentucky Wildcats points while the Wildcats practice ahead of the 2014 NCAA Men’s Final Four at AT&T Stadium on April 4, 2014 in Arlington, Texas. (Photo by Ronald Martinez/Getty Images) Twitter/@tneelOn Tuesday night, we shared a clip from Gary Parrish’s radio show, in which he told a story about John Calipari accosting a fellow coach over recruiting allegations. Kentucky Sports Radio has look further into things, and as it turns out, this story might not be a new one. KSR’s Drew Franklin found an old story from Parrish in 2010, that is largely the same as the one he told this week. The coach in question? Cincinnati’s Mick Cronin.Parrish noted that Calipari will let people know when he has problems with others and he liked the fact that he is up front. He told a story about a confrontation Calipari had with Cincinnati Coach Mick Cronin after he heard Cronin had told some associates that he didnt understand how he could go to every game for a kid and then Calipari could come in at the last minute and take him (presumably Marquis Teague). Calipari heard the comment, went to Cronin and basically said “you have to go see all the kid’s games…I can sit back and decide which kid I want and come and get them.”While we’re not totally sure that Cronin was the example given again, it does seem like this is the same story. It’d probably be hard for Calipari to get away with using the same rant too many times. This is probably not something Cincinnati basketball fans want to be reminded of too often, though.
TORONTO – It was another record close for Canada’s main stock index despite a sharp drop in the health-care sector, which includes some of the country’s biggest marijuana companies.The S&P/TSX composite index was up 41.39 points to 16,412.94, gaining ground throughout the day after flatlining earlier on Thursday amid a free fall in cannabis stocks.Pot stocks were pummelled after The Associated Press reported that U.S. Attorney General Jeff Sessions will rescind an Obama-era policy that generally barred federal law enforcement officials from interfering with marijuana sales in states where the drug is legal.“That’s added huge volatility today to the marijuana stocks. They all sold off huge in the morning, came back part way during the day and seemed to be cooling off again,” said Norman Levine, managing director of Portfolio Management Corp.“It just shows the unbelievable volatility of these groups because there aren’t really fundamentals in valuations behind it. These are emotionally driven stocks. It shows that even though the vast majority of these stocks have little to do with the United States, it doesn’t take much to set them off one way or another.”Shares of major licensed Canadian cannabis producers such as Canopy Growth Corp. (TSX:WEED) and Aphria Inc. (TSX:APH) were down 9.97 per cent and 13.79 per cent at the close of markets Thursday.South of the border, Wall Street indices also hit consecutive all-time highs as the Dow Jones industrial average breached the 25,000 mark for the first time, just five weeks since its first close above 24,000. It climbed 152.45 points to settle at 25,075.13.The S&P 500 index added 10.93 points to 2,723.99 and the Nasdaq composite index advanced 12.38 points to 7,077.92.Strong global economic growth and good prospects for higher company earnings have analysts predicting more gains for the Dow, although the market may not stay as calm as it has been recently.The Dow has made a rapid trip from 24,000 points on November 30, partly on enthusiasm over passage of the Republican-backed tax package, which could boost company profits this year with across-the-board cuts to corporate taxes.“For a long while in 2017 I would say the biggest driver was excitement and anticipation over tax reform, but at a certain point I think there was a handover to global economic growth really helping to carry the stock market,” said Kristina Hooper, chief global markets strategist at Invesco.In currency markets, the Canadian dollar closed at an average trading value of 79.90 cents US, up 0.11 of a U.S. cent.On the commodities front, the February crude contract gained 38 cents to US$62.01 per barrel and the February natural gas contract was down 13 cents to US$2.88 per mmBTU.The February gold contract was up US$3.10 to US$1,321.60 an ounce and the March copper contract added one cent at US$3.26 a pound.– With files from The Associated Press.Follow @DaveHTO on Twitter.